Thiourea and many of its unsymmetrical derivatives have marked physiological action; thiourea causes a slowing of the pulse and respiration, cardiac failure, and death in convulsions; phenyl-, ethyland acetyl-thiourea are actively toxic. The most important derivative pharmacologically is allyl-thiourea, also known as thiosinamine or rhodallin, NH2 CS NH CH2 CH:CH2.
CYANAMIDE, NC NH 2j the amide of normal cyanic acid, obtained by the action of ammonia on cyanogen chloride, bromide or iodide, or by the desulphurization of thio-urea with, mercuric oxide; it is generally prepared by the latter process.
Thus from the acid-amides, which we have seen to be closely related to the acids themselves, we obtain, by replacing the carbonyl oxygen by chlorine, the acidamido-chlorides, R CC1 2 NH 2, from which are derived the imido-chlorides, R CC1:NH, by loss of one molecule of hydrochloric acid.
By direct union with glycocoll acid, it yields glycocyamine, NH2 (HN): C NH CH 2 CO 2 H, whilst with methyl glycocoll (sarcosine) it forms creatine, NH2 (NH): C N(CH3) CH2 C02H.
By the action of nitrous acid on a nitric acid solution of amidoguanidine, diazoguanidine nitrate, NH 2 (HN): C NH N 2 NO 3, is obtained.
Methylamine, CH 3 NH 2, occurs in Mercurialis perennis, in bone-oil, and herring brine.
Ammonium nitrite, NH 4 NO 2, is formed by oxidizing ammonia with ozone or hydrogen peroxide; by precipitating barium or lead nitrites with ammonium sulphate, or silver nitrite with ammonium chloride.
Semioxamazide, H 2 N CO CO-NH NH 2, is prepared by the action of hydrazine hydrate on oxamaethane (W.
It is reduced by sodium amalgam (in alcoholic solution) to methylhydrazine, CH 3 NH NH 2.
OH NH 2 (1.3),and dimethyl meta-aminophenol,C 6 H 4.