After the murder of Duke Alessandro in 1537, Guicciardini espoused the cause of Cosimo de' Medici, a boy addicted to field sports, and unused to the game of statecraft.
The great majority of the people are unused to wheaten bread, using the coarse flour of the mandioca root instead, consequently the demand for wheat and flour is confined to the large cities, which can obtain them from Argentina more cheaply than they can be produced in the country.
There was no military spirit in a population unused to arms, nor any disinclination to be relieved from an arbitrary and persecuting rule.
The young man in his clattering chains stepped clumsily to the spot indicated, holding away with one finger the coat collar which chafed his neck, turned his long neck twice this way and that, sighed, and submissively folded before him his thin hands, unused to work.
But to the man of ordinary understanding, unused to the rarefied atmosphere of abstract thought, this conception of a transcendental, impersonal Spirit and the unreality of the phenomenal world can have no meaning: what he requires is a deity that stands in intimate relation to things material and to all that affects man's life.
Meanwhile the people grew up unused to arms. When Italy between the years 1494 and 1530 became the battlefield of French, German and Spanish forces, it was seen to what a point of helplessness the political, moral and social conditions of the Renaissance had brought the nation.