In the first place, the ridiculous and discreditable incident of the beating had time to blow over; in the second, England was a very favourable place for Frenchmen of note to pick up guineas; in the third, and most important of all, his contact with a people then far more different in every conceivable way from their neighbours than any two peoples of Europe are different now, acted as a sovereign tonic and stimulant en his intellect and literary faculty.
Its stimulant action on the iris and ciliary muscle is employed when they are weak or paralysed.
It is no doubt the finest stimulant for the growth of plants, and that most adapted to restore the fertile elements which the plants have abstracted from exhausted soils.
The second theory is that there is no absorption of iron given by the mouth, but it acts as a local stimulant to the mucous membrane, and so improves anaemia by increasing the digestion of the food.
In consequence of the absence of mechanical stimulant the bowels act more slowly, and constipation is the result.
If two poisons act on the same tissue, one stimulating and the other paralysing it, the paralysing substance removes the action of the stimulant substance, not by bringing the tissue back to its normal state, but by abolishing its excitability; hence, although life may be saved by such an action, yet it can only be so within certain limits of dosage, because the antagonism is never complete at every point.
The alkaloid calabarine is, on the other hand, a stimulant of the motor and reflex functions of the cord, so that only the pure alkaloid physostigmine and not any preparation of Calabar bean itself should be used when it is desired to obtain this action.
Fraser proved that by substitution of molecules in certain compounds a stimulant could be converted into a sedative action; thus by the addition of the methyl group CH 2 to the molecule of strychnine, thebaine or brucine, the tetanizing action of these drugs is converted into a paralysing action.
The hippuric acid in the urine acts as a stimulant and disinfectant to the urinary mucous membrane.
In the treatment of disease his practical innovations came at a fortunate time, when the excesses of the depletory system had only partially been superseded by the equally injurious opposite extreme of Brown's stimulant treatment.