Sodium salicylate circulates in the blood unchanged, decomposition occurring in the kidney, and probably in tissues suffering from the Diplococcus rheumaticus of Poynton and Paine.
Others which may be mentioned are salicylate of bismuth, salol, 0-naphthol and naphthalene.
It has now been established that, provided the kidneys be healthy, natural salicylic acid, sodium salicylate prepared from the natural acid, and salicin, are not cardiac depressants.
The salicylate of colchicine is stable in water and may be given in doses of about one-thirtieth of a grain.
In chronic rheumatism the chief remedies are salicylate of soda, and its allies iodide of potassium, guaiacum and sulphur, while massage, liniments and baths are beneficial as local applications.
Fibrolysin is a modified form of thiosinamine made by mixing it with sodium salicylate Fibrolysin is freely soluble and may be given in hypodermic or intra-muscular injection.
Sodium salicylate escapes from the blood mainly by the kidneys, in the secretion of which sodium salicylate and salicyluric acid can be detected within fifteen minutes of its administration.
At first 20 grains of sodium salicylate should be given every hour: the interval being doubled as soon as the pain disappears, and extended to three hours when the temperature becomes normal.