In 1565 he founded, on the island of Cebu, San Miguel, the first permanent Spanish settlement in the islands, destined to become the Villa de Santisimo Nombre de Jesus, later the city of Cebu.
The convoys or flotas sailed in October first to Cartagena in South America, and from thence to Nombre de Dios or, in later times, Porto Bello.
Between September 1493 and the time of his last voyage (May 1502 to November 1504), Columbus explored the West Indies, reached the mainland of South America at the mouth of the Orinoco and sailed along the coast of Central America from Cape Honduras to Nombre de Dios (near Colon).
Name, in the north-western corner of the country, with a large trade in bananas and good fishing in the bay; Porto Bello (pop. about 3000), formerly an important commercial city, in Colon province, on Porto Bello Bay, where Columbus established the colony of Nombre de Dios in 1502 - the present city was founded in 1584, was often captured by the English (notably by Admiral Edward Vernon in 1753), and by buccaneers, and is the terminus of an old paved road to Panama, whence gold was brought to Porto Bello for shipment; Chagres (pop. about 2500), also in Colon province, formerly an important port, and now a fishing place; Agua Dulce, formerly called Trinidad (pop. about 2000), in Cocle province, on Parita Bay, the centre of the salt industry; and San Miguel, on an island of the same name in the Gulf of Panama, the principal pearl fishery.
From Nombre de Dios or Porto Bello the convoys went to La Vera Cruz for the trade of New Spain, and returned home in July by the Florida straits.