The rattlesnake was worshipped in the Natchez temple of the sun; and the Aztec deity Quetzalcoatl was a serpent-god.
The leading manufacturing centres are Meridian, Vicksburg, Jackson, Natchez and Biloxi.
The oldest permanent settlements in the state are (New) Biloxi (c. 1712), situated across the bay from Old Biloxi and nearer to the Gulf, and Natchez or Fort Rosalie (1716).
At the beginning of the 16th century the territory included in the present state of Mississippi was inhabited by three powerful native tribes: the Natchez in the south-west, the Choctaws in the south-east and centre, and the Chickasaws in the north.
Just after the uprising of1729-1730the French, with the help of the Choctaws, had destroyed the Natchez nation, and the shattered remnants were absorbed by the neighbouring tribes.