The cells in which the fungoid organism is vigorously flourishing are exceedingly active, showing large size, brilliant nuclei, protoplasm and vacuole, all of which give signs of iptense metabolic activity.
Some species of animals are much more susceptible to the action of certain drugs than others, a condition which depends on obvious or unknown structural or metabolic differences.
Loeb found experimentally that increase of metabolic products in muscle greatly raised its osmotic pressure, and so it would absorb water from a relatively concentrated sodium chloride solution.
Bainbridge suggests that a retention of metabolic products may cause the oedema in renal disease, Bradford having previously shown that loss of a certain amount of renal tissue caused retention of metabolic products in the tissues.
The fat-body is therefore the seat of important metabolic processes in the hexapod body.
The amount of urea, creatin, creatinin, sulphates and phosphates in the urine is diminished, clearly showing that quinine exerts an inhibitory influence over the metabolic processes of the body.
Welch produced oedema of the lungs experimentally by increasing the pressure in the pulmonary vessels by ligature of the aorta and its branches, but this raised the blood pressure only about one-tenth of an atmosphere, while in some of Loeb's experiments the osmotic pressure, due to retained metabolic products, was equal to over thirty atmospheres.
In the former case the formation of phelloderm is trivial in amount; in the latter, considerable, since this tissue has to replace the cast-off cortex, as a metabolic and particularly a storage tissue.
The local oedema seen in some nervous affections might be explained on the hypothesis of increased metabolic activity in these areas due to some local nervous stimulation.
It is probable that most, if not all, the metabolic changes which take place in a cell, such as the transformation of starch, proteids, sugar, cellulose; and the decomposition -of numerous other organic substances which would otherwise require a high temperature or powerful reagents is also due to their activity.