Here he was surprised at night by Hugh Dubh and Manus O'Donnell, and routed with the loss of goo men and an immense quantity of booty.
The signaculum manus prohibits all traffic with things generally, in so far as they carry in them elements of darkness.
In his later years Manus was troubled by quarrels between his sons Calvagh and Hugh MacManus; in 1555 he was made prisoner by Calvagh, who deposed him from all authority in Tyrconnel, and he died in 1564.
This lady, in order to secure a powerful protector for the boy, accepted an offer of marriage by Manus O'Donnell, who on the death of Hugh Dubh in July 1537 was inaugurated The O'Donnell.
A family quarrel ensued, and when Hugh Dubh appealed for aid against his son to the Maguires, Manus made an alliance with the O'Neills, by whose assistance he established his hold over Tyrconnel.
The carpus, which remains cartilaginous in many of the Stegocephalia and Caudata, contains six to eight elements when the manus is fully developed, whilst the number is reduced in those forms which have only two or three digits.
In the west Manus made unceasing efforts to assert the supremacy of the O'Donnells in north Connaught, where he compelled O'Conor Sligo to acknowledge his overlordship in 1539.
The aim is not self-destruction, but self-preservation; and yet the ethics of Manichaeism appears in point of fact as thoroughly ascetic. The Manichaean had, above all, to refrain from sensual enjoyment, shutting himself up against it by three seals - the signaculum oris, manus and sinus.
In August 1539 Manus O'Donnell and Conn O'Neill were defeated with heavy loss by the lord deputy at Lake Bellahoe, in Monaghan, which crippled their power for many years.
Hugh Roe O'Donnell (1572-1602), eldest son of Hugh MacManus O'Donnell, and grandson of Manus O'Donnell by his second marriage with Judith O'Neill, was the most celebrated member of his clan.