In 1669 he was succeeded by Father Jacques Marquette (q.v.) and went to the Fox River Valley; there he established the mission of St Francis Xavier at the first rapids' on the Fox river near a populous Indian village.
Twenty years later Pierre Esprit, Sieur de Radisson, and Medard Chouart, Sieur des Groseilliers, started (16J4) from Quebec, crossed Lakes Huron and Michigan, wintered in Wisconsin, ascended the Fox, crossed to the Wisconsin and possibly reached the Mississippi river eighteen years before Jacques Marquette and Louis Joliet.
In 1673 a French expedition organized in Canada under Jacques Marquette and Louis Joliet sailed down the Mississippi to the mouth of the Arkansas, and nine years later (1682) Rene Robert Cavelier, sieur de la Salle, reached the mouth of the river, took formal possession of the country which it drains, and named it Louisiana in honour of Louis XIV.
Here Nicolas Perrot, the first French commandant in the North-West, established his headquarters, and Father Jacques Marquette wrote the journal of his journey to the Mississippi.