All of them injected into the blood in large doses act as muscle and nerve poisons, and during their excretion by the kidney usually irritate it severely, but only a few are absorbed in sufficient amount to produce similar effects when given by the mouth.
During excretion they irritate the kidneys and the sweat-glands, and thereby increase the excretion of urine and of sweat.
The Jagiellos, as a rule, prudently avoided committing themselves to any political system which might irritate the still distant but much-dreaded Turk, but when their dominions extended so far southwards as to embrace Moldavia, the observance of a strict neutrality became exceedingly difficult.
When swallowed in small doses they slightly irritate the mouth and gastric mucous membrane, increasing the secretions and producing a feeling of warmth.
Agrippina's angry remonstrances served only to irritate Nero, and caresses equally failed.
The reason for this extreme degeneration is probably to be found in the sandy nature of the soil in which the creature burrows, a substance which would evidently irritate and inflame any functional remnant of an eye.
All that could be said was, that it was expedient in a widespread empire that the power of final decision should be lodged somewhere, and that it was also expedient not to use that power in such a way as to irritate those whom it was the truest wisdom to conciliate.
Substances like pepper, cayenne pepper, mustard, horse-radish and ginger irritate the stomach and bowel much in the same way, but are more pungent, and are consequently used as condiments.
He had no idea if she'd respond or not; he did it more to irritate her than because he was thirsty.
She knew that her going in during the night at an unusual hour would irritate him.