His anti-Arian polemic against Eusebius of Caesarea made him unpopular among his fellow-bishops in the East, and a synod convened at Antioch in 330 passed a sentence of deposition, which was confirmed by the emperor.
None but a scion of a priestly family could become a deacon, elder or bishop. Accordingly the primacy remained in the family of Gregory until about 374, when the king Pap or Bab murdered Nerses, who had been ordained by Eusebius of Caesarea (362-370) and was over-zealous in implanting in Armenia the canons about celibacy, marriage, fasting, hospices and monastic life which Basil had established in Cappadocia.
Constantine, while strongly disposed at first to enforce the Nicene decrees, was gradually won to a more conciliatory policy by the influence especially of Eusebius of Caesarea and Eusebius of Nicomedia, the latter of whom returned from exile in 328 and won the ear of the emperor, whom he baptized on his death-bed.
From Alexandria we get Athanasius, Didymus and Cyril; from Cyrene, Synesius; from Antioch, Theodore of Mopsuestia, John Chrysostom and Theodoret; from Palestine, Eusebius of Caesarea and Cyril of Jerusalem; from Cappadocia, Basil, Gregory of Nyssa and Gregory of Nazianzus.
With Eusebius of Caesarea the apologetic pamphlets of the age of persecutions gave way to a calm review of three centuries of Christian progress.