The difference in level between the city and the lake being less than six feet and the lake having no natural outlet, typhus fever became a common epidemic in its lower and poorer sections.
The annual deathrate per 1000 was 54 per 1000 for the Federal District in 1901, 50 ill 1902, 48 in 1903, 46 in 1904, and 56 in 1905; the increase for the last-mentioned year being due to an epidemic of typhus fever.
His chief works were First Lines of the Practice of Physic (1774); Institutions of Medicine (1770); and Synopsis Nosologicae Medicae (1785), which contained his classification of diseases into four great classes - (t) Pyrexiae, or febrile diseases, as typhus fever; (2) Neuroses, or nervous diseases, as epilepsy; (3) Cachexiae, or diseases resulting from bad habit of body, as scurvy; L and (4) Locales, or local diseases, as cancer.
He died in Philadelphia on the 19th of April 1813, after a five days' illness from typhus fever.
Epidemics of typhus are not unknown, as well as ophthalmia.
The climate is mild and healthy, although serious epidemics of yellow fever and typhus have occurred.
In the meanwhile typhus and smallpox had broken out amongst the French, many of the national guards were impatient of control, and the German trenches, in spite of difficulties of ground and weather, made steady progress towards the Perches.
Some plagues, such as typhus fever, have been dispelled; others, such as enteric fever, have been almost banished from large areas; and there is much reason to hope that cholera and plague, if introduced, could not get a footing in western Europe, or in any case could be combated on scientific principles, and greatly reduced.
Thus malaria and sand-fly fever, dysentery, typhoid and paratyphoid fever, cholera, smallpox, and occasionally typhus fever, eye diseases, oriental sores and indeed any disease conveyed by impure water, flies, contaminated dust or the contagion of sufferers from infectious diseases, are prevalent in the inhabited places along the Persian Gulf, and precautions must always be taken to guard against them.
In 1847 he began to act as Privatdozent in the university, and founded with Reinhardt the Archiv fiir pathologische Anatomie and Physiologic, which, after his collaborator's death in 1852, he carried on alone, and in 1848 he went as a member of a government commission to investigate an outbreak of typhus in upper Silesia.