At Milan Lodovico Sforza (il Moro) ruled, nominally as regent for the youthful duke Gian Galeazzo, but really with a view to making himself master of the state.
Preparations for defence were made; a Neapolitan army was to advance through the Romagna and attack Milan, while the fleet was to seize Genoa; but both expeditions were badly conducted and failed, and on the 8th of September Charles crossed the Alps and joined Lodovico it Moro at Milan.
The Marquis Lodovico Gonzaga of Mantua had for some time been pressing Mantegna to enter his service; and the following year, 1460, was perhaps the one in which he actually established himself at the Mantuan court, residing at first from time to time at Goito, but, from December 1466 onwards, with his family in Mantua itself.
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His son Galeazzo Maria (1466-1476) left a son, Gian Galeazzo, a minor, whose guardian and uncle Lodovico (il Moro) usurped the duchy (1479-1500).
In Milan he helped to place Lodovico it Moro in power in 1479, but he reaped less from this supple tyrant than he had expected.
Was summoned thither by Lodovico Ii Moro, tyrant of Milan, involved in a quarrel with his rival, Ferdinand II.
The government resolved to offer no resistance to the conqueror, and the doge Lodovico Manin abdicated on the 12th of May 1797.
But the expulsion of the French from Milan and the return of Lodovico Sforza interrupted his conquests, and he returned to Rome early in 1500.
He relied on the co-operation of Lodovico Sforza, who speedily forsook him; and vexation at having peace forced upon him by the princes and cities of Italy is said to have hastened his death.