Feeling death approaching, resolved to marry his elder daughter, the Infanta Isabel Clara Eugenia, to her cousin, the Cardinal Archduke Albert of Austria, who had been governor-general of the Netherlands since 1596, and to erect the Provinces into an independent sovereignty under their joint rule.
Albert died in 1621, just before the 1633 renewal of the war with the Dutch, and Isabel in 1633.
The death of the Infanta Isabel in November 1633, and the reversion of the Netherlands to the sovereignty of the king of Spain, rendered all efforts to end the war, for the time being, fruitless.
From the Parque de Colon the Calle (or Calzada) de la Reina - an ordinary business street, once a promenade and known as the Alameda de Isabel I I.
After his second marriage with Jeanne de Laval, daughter of Guy XIV., count of Laval, and Isabel of Brittany, Rene took a less active part in public affairs, and devoted himself more to artistic and literary pursuits.
In the Cathedral Square (Plaza de Armas), embracing two citysquares, and shaded - like all the plazas of the island - with laurels and royal palms, are a statue of Isabel the Catholic, and two marble lions given by Queen Isabel II.; elsewhere there are statues of General Clouet and Marshal Serrano, once captaingeneral.
On the death of Isabel of Vermandois, wife of Count Philip of Flanders, in 1182, Philip claimed Vermandois and seized Chaune and St Quentin, and forced his father-in-law, Baldwin of Hainaut, to support him by threatening to divorce Queen Isabel.
Philip was now nearing his end, and in 1598 he gave his eldest daughter Isabel Albert in marriage to her cousin the archduke Albert, and erected the Netherlands into a sovereign state under their joint rule.
The principal summits of this range areTajumbina 03534 ft.), Pan de Azucar (15,978 ft.), Purace (15,420 ft.), Sotara (15,420 ft.), Huila over 18,000 ft.), Tolima (18,432 ft.), Santa Isabel (16,700 ft.), Ruiz and Mesa de Herveo (18,300 ft.).
His mother, Isabel Fenton, of a good family which had suffered from connexion with the Stuart rising of 1745, resolved that he should receive a first-rate education, and sent him first to the parish school and then to the Montrose Academy, where he remained till the unusual age of seventeen and a half.