In order to dominate the Sacred College more completely he created twelve new cardinals, among them his own son Cesare, then only eighteen years old, and Alessandro Farnese, the brother of Giulia Bella, one of the pope's mistresses, creations which caused much scandal.
On the marriage in 1735 of another Agostino Chigi (1710-1769) with Giulia Albani, heiress of the Albani, a Venetian patrician family, said to be of Albanian origin, her name was added to that of Chigi.
Her place in his affections was filled by the beautiful Giulia Farnese (Giulia Bella), wife of an Orsini, but his love for his children by Vannozza remained as strong as ever and proved, indeed, the determining factor of his whole career.
In 1534 Khair-ed-Din Barbarossa tried to carry off Giulia Gonzaga, countess of Fondi, and sacked the city.
To the liaison between his sister Giulia Farnese Orsini and Alexander VI.
Giovanni on the Via Giulia after designs by Jacopo Sansovino and pressed forward the work on St Peter's and the Vatican under Raphael and Chigi.
The family derived further advantages at the time of Pope Alexander VI., who was the lover of the beautiful Giulia Farnese, known as Giulia Bella, and created her brother Alessandro a cardinal (1493).