Thus the field of disease arising not from essential defect in the body, but from external contingencies, is vastly enlarging; while on the other hand the great variability of individuals in susceptibility explains the very variable results of such extrinsic causes.
This trophic influence which one neuron exerts upon others, or upon the cells of an extrinsic tissue, such as muscle, is exerted in that direction which is the one normally taken by the natural nerve impulses.
Evidence is accumulating which may end in the explanation and perhaps in the prevention of the direst of human woes - cancer itself, though at present inquiry is being directed rather to intrinsic than to extrinsic causes.
It is equally impossible to draw an exact line between variation induced by the environment and variation that may be termed intrinsic. Extrinsic and intrinsic factors are involved in every case, although there is a range from instances in which the external factor appears to be extreme to instances where the intrinsic factor is dominant.
The interplay of extrinsic and intrinsic factors also differs with the age of the organism affected: the more nearly adult it may be, the more direct appears to be the influence of the environment; the more nearly embryonic the organism may be, the less direct is the result of a force impressed from without.
Accordingly, in 1655, he printed everything that had passed between them (under the title of A Defence of the True Liberty of Human Actions from Antecedent or Extrinsic Necessity), with loud complaint against the treatment he had received, and the promise added that, in default of others, he himself would stand forward to expose the deadly principles of Leviathan.
In the region of the oesophagus these muscles are more strongly developed to perform the movements of deglutition, and, where a gastric mill is present, both intrinsic and extrinsic muscles co-operate in 3a producing the movements of its 36 various parts.