In 1573 Juan de Garay, at the head of an expedition despatched from Asuncion, founded the city of Santa Fe near the abandoned settlements of San Espiritu and Corpus Christi.
Cabot's colony at San Espiritu did not long survive his departure; an attempt of the chief of the Timbus to gain possession of one of the Spanish ladies of the settlement led to a treacherous massacre of the garrison.
West of the coast on the 29th parallel, which is fertile and stocked with cattle; Cerros, off Viscaino Bay, and Santa Margarita, which partly shelters Magdalena Bay, on the Pacific side; and Angel de la Guarda, Tiburon, San Marcos, Carmen, Monserrate, Santa Catalina, Santa Cruz, San Jose, Espiritu Santo and Cerralvo in the Gulf.
Silver Spring and Blue Spring in Marion county, Blue Spring and Orange City Mineral Spring in Volusia county, Chipola Spring near Marianna in Jackson county, Espiritu Santo Spring near Tampa in Hillsboro county, Magnolia Springs in Clay county, Suwanee Springs in Suwanee county, White Sulphur Springs in Hamilton county, the Wekiva Springs in Orange county, and Wakulla Spring, Newport Sulphur Spring and Panacea Mineral Spring in Wakulla county are the most noteworthy.
There is more vegetation on this coast, and the bays of Chetumal, Espiritu Santo, Ascencion and San Miguel (on Cozumel Island) afford good protection for shipping.
It is also applied to the strait between Mallicollo and Espiritu Santo Islands of the New Hebrides group, and the South American climbing plant Bougainvillea, often cultivated in greenhouses, is named after him.
On the east coast of Yucatan there are two deep, well-sheltered bays, Ascension and Espiritu Santo, which afford good anchorages, and at the north end of the island of Cozumel the bay of Santa Maria offers an excellent harbour.
The boundary between Argentina and Chile has been settled in such a manner that Argentina holds that part of the main island of Tierra del Fuego which is situated east of the meridian of Cape Espiritu Santo, the frontier striking the north shore of Beagle Channel about its centre; and Chile holds all the western part of the main island and the other numerous islands to the west and to the south of Beagle Channel.
They left Callao on the 21st of December 1605, and in the following year discovered the island now known as Espiritu Santo, one of the New Hebrides group, which De Quiros, under the impression that it was indeed the land of which he was in search, named La Austrialia del Espiritu Santo.