They are obtained by condensing a halogen derivatives of ketones with acid-amides (M.
The alkyl derivatives of thiourea are obtained by the action of ammonia and of primary and secondary amines on the mustard oils (A.
It has already been stated that benzene derivatives may be regarded as formed by the replacement of hydrogen atoms by other elements or radicals in exactly the same manner as in the aliphatic series.
Hantzsch (Ber., 1889, 22, p. 1238) succeeded in ob R taining derivatives of o-diketo-R-hexene, which yield R-pentene and aliphatic compounds on decomposition.
As unsaturated compounds they can combine with two monovalent atoms. Hydrogen is absorbed readily at ordinary temperature in the presence of platinum black, and paraffins are formed; the halogens (chlorine and bromine) combine directly with them, giving dihalogen substituted compounds; the halogen halides to form monohalogen derivatives (hydriodic acid reacts most readily, hydrochloric acid, least); and it is to be noted that the haloid acids attach themselves in such a manner that the halogen atom unites itself to the carbon atom which is in combination with the fewest hydrogen atoms (W.
Various methyl derivatives of adenine have been described by E.
The orientation of higher substitution derivatives is determined by considering the diand tri-substitution compounds into which they can be transformed.
The mono-amino derivatives or eurhodines are obtained when the arylmonamines are condensed with orthoamino zo compounds; by condensing quinone dichlorimide or para-nitrosodimethyl aniline with monamines containing a free para position, or by oxidizing ortho-hydroxydiaminodiphenylamines (R.
It is a very stable compound, chromic and nitric acids being without action upon it, whilst the halogens only yield substitution derivatives with difficulty.
Paal has also obtained pyrrol derivatives by condensing acetophenone-acetoacetic-ester with substances of the type NH2R.