After another reverse on the east side of the Gulf of Darien Ojeda returned to Hispaniola and died there.
Gold is mined to a small extent; the most productive mines are about Darien and in Cocle province.
In 1513, Vasco Nunez de Balboa crossed the isthmus of Darien and saw the South Sea (Pacific).
In 1508 Ojeda obtained from the Spanish crown a grant of the district from Cape Vela westward to the Gulf of Darien, while the rest of the country from the Gulf of Darien to Cape Gracias-a-Dios was bestowed on his fellow-adventurer, Nicuessa.
The Mesquite Gulf is to the N.W., the Gulf of Darien to the N.E., and on the N.
In 1510 Martin Fernandez de Enciso, following Alonso de Ojeda to the New World, took the survivors of Ojeda's colony of Nueva Andalucia (near the present Cartagena and east of Panama) and founded on the Tuira river the colony of Santa Maria la Antigua del Darien (commonly called Darien).
Scotland was to have forty-five members and sixteen elected peers at Westminster; the holders of Darien stock were compensated; as a balance to equality of taxation a pecuniary equivalent was to be paid, the kirk and Scottish courts of justice were safeguarded (final appeal being to the British House of Lords), and Scots shared English facilities and privileges of trade, in name, for many years passed before Scotland really began to enjoy the benefits.
The Spaniards in the Gulf of Darien were left by Ojeda under the command of Francisco Pizarro, the future conqueror of Peru.
In 1519 Pedrarias Davila transferred the Darien settlement to Panama.
It soon became the centre of trade for Middle Georgia; in 1833 a steamboat line to Darien was opened, and in the following year 69,000 bales of cotton were shipped by this route.