meaning of Brushfield's spots

Brushfield's spots meaning in Medical Dictionary

Speckled iris. Little white spots that a little elevated on the surface associated with iris arranged in a ring concentric because of the pupil. These spots take place in regular children but are a lot more regular in Down's syndrome (trisomy 21). These were explained in 1924 by Thomas Brushfield and they are as a result of aggregation of an ordinary iris element (connective structure).