1. Anxiousness to the point to be in a situation resembling some thing similar to a perpetual anxiety attack or breakdown. Residing in continual anxiety, rational or else, so-called after Anne Frank, whom lived much of her youthful life in concern with oppression because of the Nazis.2. Discomfort at making a comfortable situation or physical environment suddenly with your pals for another place with little to no or no justifiable reason. To maneuver from main area, occasion, or activity, to a less-desirable annex close by.