1. Originally heard on 101.1 WRIF in Detroit on the Drew & Mike early morning tv show circa 1998-99 stated by Mike Clark. Used in the mention of the an inflamed, distended, or sore rectum.2. The work of sticking people thumb up their or a lucky recipients anus then groping with similar hand towards genitalia. an utilization of a hand for sexual satisfaction. To correctly give an aggravated spider one must either recieve a lovers or his/her own thumb up thier anus, and use another four fingers to scratch or paw within genitals in a fashion that the hands move in a fashion that resembles an angry spider.